Despite the initial evidence on the role of zinc and zinc transporters in cancer prevention,\nlittle attention has been paid to the zinc-derived compounds. In the present work, we reported a\nstrategy to prepare a kind of zinc-releasing container with enhanced biocompatibility and release\ndynamics using ZIF-8 nanocrystals as the sacrificial templates. Transmission electron microscopy\n(TEM) analysis demonstrated that the ZIF-8 nanocrystals were gradually etched out in the aqueous\nmedia within 48 h, resulting in hollow nanocapsules. Notably, we found the self-polymerization of\ndopamine can form nanoshells around the ZIF-8 nanocrystals, which served as a type of functional\nmembranes during the release of zinc. More interestingly, PDA@ZIF-8ââ?¬â??based nanohybrids expressed\nstronger inhibition to the cancer cell growth, which implied that the nanohybrids could be a drug\ncarrier for chemotherapy. This study broadens the biomedical application of ZIF-8 and also provides\na versatile strategy toward the development of multifunctional delivery system.
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